In Bootstrap 5, creating a responsive two-column layout is straightforward using the grid system. You can use the "row" and "col" classes to define columns that adjust based on the screen size.

<!-- BEGIN COPY / PASTE -->
        <div class="container">
            <div class="row">
                <div class="col-md-6">
                    <!-- Content for the first column -->
                    <p>Column 1</p>
                </div>
                <div class="col-md-6">
                    <!-- Content for the second column -->
                    <p>Column 2</p>
                </div>
            </div>
        </div>
        <!-- END COPY / PASTE -->

1. The "container" class centers your content and provides padding.
2. The "row" class is used to create a horizontal group of columns.
3. The "col-md-6" class specifies that each column should take up half the width on medium-sized screens and larger.
4. On smaller screens, columns stack vertically by default.